Radiation therapy is an effective way to control malignancies. But the side effects of radiation therapy are among the challenges in treating malignancies. The most common complication of malignant radiation therapy is tissue damage following therapy. These lesions occur in a variety of tissues, including bone tissue. Blood supply to the bones is naturally very limited (bones are vessel poor group); As a result, compensating these injuries is very difficult and sometimes impossible. Radiotherapy-induced bone damage is abbreviated to "osteoradionecrosis" (osteo-bone, radi-radiation, and necrosis-damage).

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