The human skin is a protective shield against germs therefore, any defect in the skin (called a wound) can increase the chances of micro-organisms invading and the wound becomes infected. When a wound occurs, the body's immune system is activated by immune cells attacking the infected areas. In cases with severe infections, large wounds, or immunodeficiencies antibiotic therapy is needed. In diabetic patients, both weakened immune systems and impaired blood flow (capillary damage) cause diabetic wounds, especially in the foot (diabetic foot), which become more severely infected and worsens the condition. Certainly, due to the lack of blood supply to these wounds, "anaerobic micro-organisms" are more likely to cause infections. However, gram-negative micro-organisms also infect these wounds, and in more advanced wounds, gram-positive germs are also present in the wound. In this case, three-way treatment or "triple therapy" will be needed. A more complete method would be sampling of the wound surface and culture and antibiogram based on which antibiotic treatment can be performed. 

"Hyperbaric Oxygen Therapy" provides an oxygen riched tissue environment which has antimicrobial effects, modulates the immune system, and is suitable for capillary formation (micro-angiogenesis). The mentioned micro-angiogenesis, by transfer antibiotics to the wound site would heal infections. Therefore, a proper antibiotic regimen would be necessary for the proper treatment of diabetic wounds.